Preclinical contract research: animal models of neurological disorders:
Preclinical Stroke models
Large-vessel occlusion (modified MCAO)
This model mimics a particular clinical condition seen following ischemic stroke, large vessel occlusion, and permits direct delivery of a potential therapeutic to the injury site. Focal ischemia is first induced by occlusion of the CCA/MCA, followed by rapid recanalization, then direct IA injection of a potential neurotherapeutic agent. Click here for a full description of this model.
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