Preclinical contract research: animal models of neurological disorders:

Large-vessel occlusion (modified MCAO)
 

This model mimics a particular clinical condition seen following ischemic stroke, large vessel occlusion, and permits direct delivery of a potential therapeutic to the injury site.  Focal ischemia is first induced by occlusion of the CCA/MCA, followed by rapid recanalization, then direct IA injection of a potential neurotherapeutic agent.  Click here for a full description of this model.