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Aged rats
The FBN/F1 hybrid strain displays selective cognitive impairments beginning in late middle age, at a time when there is no general learning deficit, which develops later. Potential therapies are tested in several types of mazes, including the watermaze, the modified Barnes maze (foraging/hoarding task), and T-maze.
To view two example studies [Click here 1; Click here 2]
Long Evans aged rats also display cognitive deficits, and are also used for testing potential cognitive enhancers.
For an example publication [Click here]
Scopolamine impaired rat and dog
Cholinergic impairment is a feature of age-related cognitive decline in some dementias. Impairment of central cholinergic functioning by scopolamine is therefore used as a pharmacologic model for testing certain cognition-enhancing therapeutics, such as cholinesterase inhibitors. NDI offers both scopolamine treated rats and dogs as models of cognitive impairment.
For an example study [Click here]
Aged rhesus monkey
Aged rhesus monkeys show several cognitive deficits that have been linked to MCI. The most often-used test is the Delayed Match to Sample (DMTS).
For an example study [Click here]
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