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Preclinical contract research: animal models of neurological disorders:
Preclinical Down's Syndrome / Fragile X Syndrome models
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Established mutant mouse models of both Fragile X Syndrome (Fmr-1-/-) and Down's Syndrome (Ts65Dn) are available, along with a unique model FRAXAD. The latter is a cross between the well known Alzheimer's model (Tg2576) and Fmr-1-/- mice. FRAXAD mice over-express human AbPP with the Swedish mutation in an Fmr-1-/- background. (For an example study [Click here])
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